Compatibility and stability of polygeline (Haemaccel) with different brands of cefotaxime

摘要

Compatibility of the polygeline-based blood plasma expander Haemaccel with cefotaxime sodium was examined in the context of its potential use in circulatory insufficiency, in threatened and established shock, because drug stability and compatibility are critical elements in the accurate and appropriate delivery of drug therapy to patients. Treatment, safety, acceptability and efficacy may be affected by drug instability or incompatibility. This study was initiated to specifically and critically assess the compatibility of Haemaccel with cefotaxime sodium with the aim of delivering safe, appropriate, acceptable and efficacious administration of two different drug products simultaneously in emergency situations.