Anti-ictogenic and antiepileptogenic properties of brivaracetam in mature and immature rats

Dupuis Nina; Matagne Alain; Staelens Ludovicus; Dournaud Pascal; Desnous Beatrice; Gressens Pierre; Auvin Stephane

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Anti-ictogenic and antiepileptogenic properties of brivaracetam in mature and immature rats

机译：Brivaracetam在成熟和未成熟大鼠中的抗致晕药和抗癫痫药特性

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ObjectiveBrivaracetam (BRV) is a new antiepileptic drug candidate rationally designed for high affinity and selectivity for the synaptic vesicle protein 2A. This study explored anti-ictogenic and antiepileptogenic effects of BRV in rats at different stages of development.

机译：目的Brivaracetam（BRV）是一种新的抗癫痫药候选药物，经过合理设计，可对突触小泡蛋白2A具有高亲和力和选择性。这项研究探讨了BRV在大鼠不同发育阶段的抗致烟性和抗癫痫作用。

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来源
《Epilepsia: Journal of the International League against Epilepsy》 |2015年第5期|共6页
作者
Dupuis Nina; Matagne Alain; Staelens Ludovicus; Dournaud Pascal; Desnous Beatrice; Gressens Pierre; Auvin Stephane;
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正文语种 eng
中图分类神经病学;
关键词
Antiepileptic drugs; Brivaracetam; Epileptogenesis; Kindling; Rat;

机译：抗癫痫药;布雷西酰胺;癫痫发生;金德林;大鼠;

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1. Anti-ictogenic and antiepileptogenic properties of brivaracetam in mature and immature rats [J] . Dupuis Nina, Matagne Alain, Staelens Ludovicus, Epilepsia: Journal of the International League against Epilepsy . 2015,第5期

机译：Brivaracetam在成熟和未成熟大鼠中的抗致晕药和抗癫痫药特性
2. Treatment of Experimental Status Epilepticus in Immature Rats: Dissociation Between Anticonvulsant and Antiepileptogenic Effects [J] . Lucie Suchomelova, Roger A Baldwin, Hana Kubova, Pediatric Research . 2006,第2期

机译：未成熟大鼠实验状态癫痫的治疗：抗惊厥药和抗癫痫药作用的分离
3. Composition, physicochemical properties and thermal inactivation kinetics of polyphenol oxidase and peroxidase from coconut (Cocos nucifera) water obtained from immature, mature and overly-mature coconut [J] . Thuan-Chew Tan, Lai-Hoong Cheng, Rajeev Bhat, Food Chemistry . 2014,第jana1期

机译：从未成熟，成熟和过成熟的椰子获得的椰子水中的多酚氧化酶和过氧化物酶的组成，理化性质和热灭活动力学
4. Stress exposure using small mobile robot both in immature and mature period induces mental disorder in rat [C] . Ishii Hiroyuki, Shi Qing, Miyagishima Syunsuke, 2012 4th IEEE RAS amp; EMBS International Conference on Biomedical Robotics and Biomechatronics . 2012

机译：使用小型移动机器人在未成熟和成熟期承受的压力暴露会导致大鼠精神障碍
5. Developmental-associated differences in membrane cholesterol content play a defining role in the response of transitional immature and mature B cells upon B cell receptor engagement [D] . Karnell, Fredrick G., III 2008

机译：膜胆固醇含量的发育相关差异在B细胞受体参与后过渡性未成熟B细胞和成熟B细胞的反应中起决定性作用
6. Comparison of mechanical and histological properties between the immature and mature tendon attachment [O] . Kazutoshi Furikado, Hiroyuki Fujioka, Masahiro Kurosaka, 2002

机译：未成熟和成熟肌腱附着之间的力学和组织学性质比较
7. Anti-ictogenic and antiepileptogenic properties of brivaracetam in mature and immature rats [O] . Dupuis, Nina, Matagne, Alain, Staelens, Ludovicus, 2015

机译：Brivaracetam在成熟和未成熟大鼠中的抗致晕药和抗癫痫药特性

Anti-ictogenic and antiepileptogenic properties of brivaracetam in mature and immature rats

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