Antiproliferative activities of methanolic extracts from a neotropical Ganoderma species (Aphyllophoromycetideae): identification and characterization of a novel ganoderic acid.

摘要

The present study aims to compare antiproliferative activities of different methanolic extracts from French-Antillean and Guianese species of Ganodermataceae Donk and two reference species: European G. lucidum and Asian "G. lucidum," on human prostate cancer (PC-3), human breast adenocarcinoma (MCF-7), and human colon adenocarcinoma grade II HT29. We demonstrated that antiproliferative activity from European G. lucidum is similar to the "G. lucidum" traditionally used in Asian medicine except for HT29 cancer cells, where no activity has been demonstrated for the Asian species. We also show that some Neotropical Ganoderma such as Ganoderma aff. tuberculosum could also inhibit the growth of cancer cells as well as or better than "G. lucidum," which is used in traditional Asian Medicine and European G. lucidum. Standards GA A, GA DM, and GA F previously reported to have antiproliferative activities were not found in methanolic extracts of Ganoderma aff. tuberculosum. On the contrary, methanolic extracts of this species contains the same major, and at present undescribed, ganoderic acid FWI. Thus, although demonstrating no significant activity on PC3, MCF-7, and HT29, GA FWI remains interesting as a taxonomic marker for this species.