Using a combination of simulations of alamethicin and other antimicrobial peptides in different environments, M e discuss a number of pertinent problems in the biophysics of peptide-lipid interactions and ion channels. Molecular dynamics simulations can be used to obtain detailed information about the structure and dynamics of peptides in membrane environments. Such simulations have yielded interesting information on the dynamics of membrane proteins and of water and ions in ion channels. However reliably simulating binding to membranes, insertion into membranes, and aggregation of peptides both in and at the surface of membranes remain challenging problems. (C) 2001 John Wiley & Sons, Inc. [References: 94]
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机译：M e在不同的环境中结合使用了拟除虫菊酯和其他抗菌肽的模拟，讨论了肽-脂质相互作用和离子通道的生物物理学中的许多相关问题。分子动力学模拟可用于获得有关膜环境中肽的结构和动力学的详细信息。这样的模拟产生了有关膜蛋白以及离子通道中水和离子动力学的有趣信息。然而，可靠地模拟与膜的结合，插入膜中以及膜内和表面上肽的聚集仍然是具有挑战性的问题。 （C）2001 John Wiley＆Sons，Inc. [参考：94]
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