Fabrication of rectorite-contained nanoparticles for drug delivery with a green and one-step synthesis method

摘要

The composite nanoparticles (NPs) consisted of quaternized chitosan (QC)/bovine serum albumin (BSA)/ rectorite (REC) were prepared successfully just by adding BSA solution into QC-REC nanocomposites solution via electrostatic interactions. The average diameter of NPs increased with the accretion of REC, which was demonstrated with dynamic laser scattering (DLS) and transmission electron microscopy (TEM). The results of small angle X-ray diffraction (SAXRD) and selected area electron diffraction (SAED) demonstrated that the intercalated structure of REC was enlarged with the addition of REC. Besides, it can was proved that the interaction had occurred between QC and REC in NPs with fourier transform infrared (FT-IR) and X-ray photoelectron spectroscopy (XPS). In addition, doxorubicin (DOX) was used to investigate the entrapment efficiency and release pattern in NPs. It turned out to be that the addition of REC could increase the encapsulation efficiency (EE) and loading capacity (LC). The results also exhibited that the drug release in simulated gastric fluid reduced apparently with the addition of REC, which could ensure more DOX released in intestines. (C) 2015 Elsevier B.V. All rights reserved.