Novel abciximab-Kruppel-like factor 4-plasmid dual-delivery titanium dioxide-coated coronary stent

摘要

Although previous studies [1,2] showed that local gene delivery was effective in atherosclerotic lesions, the low efficiency remained problematic. To overcome the low efficiency of gene delivery, several researchers have attempted local and direct gene delivery by use of an intravascular steht with a denatured polymer coating.However, therapeutic gene delivery did not show an inhibitory effect on ISR equivalent to that of DES using sirolimus or paditaxel. Therefore, in this article, we investigated whether dual delivery of both abciximab and Kruppel-like factor 4 (KLF4) plasmid, presented as regulation factor of vascular smooth muscle cell proliferation and differentiation using titanium dioxide (TiO2) coating [3] stent could be effective for inhibiting in stent restenosis (ISR) in coronary arteries.