Acute effect of sildenafil on hypoxemic patients (excluding those with Eisenmenger syndrome) with incurable congenital heart disease and disturbed pulmonary vasculature in the mid-term follow-up.

摘要

Cyanotic patients associated with complex heart disease, which is incurable due to disturbed pulmonary vasculature, are complicated with functional impairment and various systemic disorders in the long-term [1]. Phosphodiesterase (PDE) type 5 inhibitors improve oxygen saturation in patients with Eisenmenger syndrome or in patients with interstitial lung fibrosis [2,3]- Management ofhypox-emic CHD patients, who were not indicated for further corrective surgery due to inappropriate pulmonary vasculature other than typical pulmonary arterial hypertension, is an evolving issue in developed countries with few new cases of Eisenmenger syndrome. We hereby report our initial observations regarding the acute effects of sildenafil on oxygen saturation in hypoxemic CHD patients, excluding those with Eisenmenger syndrome, who are accompanied by inappropriate pulmonary vascular bed in univentricular physiology after cavopulmonary connection or severely hypoplastic pulmonary artery in tetralogy-like biventricular physiology, in the early and mid-term follow-up period.