Bioavailability Following Oral Administration of a Silibinin-Phosphatidylcholine Complex in Cats

摘要

The current study determined the intravenous and oral bioavailability of a silibinin-phosphatidylcholine complex (SPC) in cats. Five adult cats were given a single oral dose (10 mg/kg) of SPC and plasma silibinin levels were measured at various time points for 12 hours post-administration. Following a 2-week washout period, a single intravenous dose of SPC (50 mg/cat) was given and plasma silibinin levels were determined at similar time intervals. A pharmacokinetic (PK) comparison of IV silibinin vsoral dosing of SPC in cats showed the following: C_(max) of 87.1 ± 44.2 IV and 5.8mu M ± 3.1 oral; AUC(0->inf), of 86.6 mu M-hr ± 81.4 IV and 6.1 mu M-hr 3.5 oral; tl/2X of 2.51hr ± 1.63 IV and 3.16hr ± 1.74 oral; Vz/F of 5.65L± 3.66 IV and 309L ±165 oral; and CL/F of 1.88L/hr ± 0.99 IV to 74.7L/hr ± 47.1 oral. Oral SPC has a bioavailability of approximately 7% in the cat. Although the hepatic levels of silibinin were not determined in this study, the bioavailability of SPC in cats is an initial step towards determining its effectiveness as a hepatoprotective antioxidant for use in cases of feline liver disease.