A procedure for non-invasive imaging of the optical attenuation coefficient variation of in vivo thick organs/tissues is developed. The laser back-scattered surface profiles at various locations of human forearm, by multi-probe reflectometer, are measured. These profiles are matched by iterative procedure, with that as obtained by Monte Carlo simulation and the corresponding values of attenuation coefficient (equal to the sum of absorption and reduced scattering coefficients) are determined. By interpolation of this data a 100 X 100 grid is constructed and after median filtering of this data a color-coded image of the variability of the optical attenuation coefficient of the forearm is obtained. These images in different subjects show variation dueto change in overall tissue composition and blood pooling. This non-invasive imaging procedure may help in identifying the diseased affected regions in healthy tissues and in application of photodynamic therapy.
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机译：开发了用于体内厚壁器官/组织的光学衰减系数变化的非侵入性成像的程序。用多探针反射仪测量在人的前臂各个位置的激光后向散射表面轮廓。这些轮廓通过迭代过程进行匹配，并与通过蒙特卡洛模拟获得的轮廓进行匹配，并确定相应的衰减系数值（等于吸收系数和减少的散射系数之和）。通过对该数据进行插值，构建了一个100 X 100的网格，并在对该数据进行中值滤波之后，获得了前臂光衰减系数可变性的彩色编码图像。这些图像在不同的对象中显示出由于整体组织组成和血液汇集的变化而引起的变化。这种非侵入性成像程序可能有助于识别健康组织中的患病区域，并有助于光动力疗法的应用。
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