Catalytic Cycloisomerization-Fluorination Sequence of N-Propargyl Amides by Iodoarene/HFPyridine/Selectfluor Systems

摘要

As a first example of metal-free and catalytic fluorinative transformations of alkynes, we developed a cycloisomerization-fluorination sequence of N-propargyl amides catalyzed by an iodine(III) species. The iodine(III) catalyst is in situ generated from iodoarene as a precatalyst with Selectfluor as a fluorinating oxidant in the presence of HFpyridine.