Synthesis of Hydantoin,Thiohydantoin and Desulphuration of Thiohydantoin to Hydantoint

摘要

Condensation of benzil(or alpha-diketone obtained from auroneepoxide)with urea,thiourea and substituted thiourea in presence of ethanol in alkaline medium leads to the formation of hydantoin,thiohydantoin and substituted thiohydantoin.All the compounds were purified and analyzed using physical and chemical methods and were further confirmed by spectral studies.The antimicrobial effect was studied by using cup-plate(nu-trient-agar)technique on six different pathogenic microorganisms.The synthesised compounds were screened for their anti-AIDS property.