Successful treatment of adult-onset Still's disease refractory to TNF and IL-1 blockade by IL-6 receptor blockade.

摘要

Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown aetiology. Based on the substantial acute phase responses observed in AOSD, we hypothesised that blockade of the interleukin 6R (IL-6R), neutralising the induction of the acute phase response by IL-6, could be a useful treatment in multidrug-resistant AOSD. We here report on three patients with AOSD who were refractory to standard treatment and cytokine blockade with anakinra and tumour necrosis factor (TNF) block-ers and were subjected to treatment with tocilizumab. The characteristics of these three patients are summarised in table 1.