Fecal calprotectin in allogeneic stem cell transplantation for the diagnosis of acute intestinal graft versus host disease

摘要

Intestinal symptoms are common after hematopoietic SCT (HSCT). In this setting, differential diagnosis specifically for diarrhea includes infections, conditioning regimen toxicity and intestinal GVHD (IGVHD), among others. The importance of an early and accurate diagnosis lies in the different therapeutic approaches, outcome and prognosis. The gold standard for the diagnosis of acute IGVHD is endoscopy,1 which sometimes yields non-specific findings and is an invasive procedure,2 and histological confirmation with the demonstration of intracryptal apoptosis.