Background: Central blood flow measurements can provide detailed information on the hemodynamic condition of the preterm infant. However, reference values for right and left ventricular output (RVO and LVO) and superior vena cava flow (SVC flow) are only available for infants in the transitional period. The aim of this study was to determine RVO, LVO and SVC after the transitional period in stable preterm infants. Methods: RVO, LVO and SVC flow were measured with functional echocardiography on days 7 and 14 of life in stable preterm infants less than 32 weeks gestation, with minimal respiratory support and no cardiovascular support. Infants with a clinical suspicion of an infection within 48 h after data collection or a ductal diameter >1.4 mm were excluded from analysis. Results: We performed 111 measurements in 62 preterm infants with a median (range) gestational age of 28 (25-31) weeks and birth weight of 1105 (650-2370) g. 57 measurements were analysed on day 7 and 47 on day 14. The mean (SD) RVO, LVO and SVC flow were 429 (116), 296 (74) and 89 (33) ml/kg/min on day 7 and 433 (81), 300 (79) and 86 (26) ml/kg/min on day 14. There were no significant differences in flows between days 7 and 14 in the paired measurements. Conclusion: This study provides central blood flow values in stable preterm infants after the transitional period. The flow variables were shown to remain stable between days 7 and 14.
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机译：背景：中央血流测量可以提供有关早产儿血液动力学状况的详细信息。但是，左右心室输出（RVO和LVO）和上腔静脉血流（SVC血流）的参考值仅适用于过渡时期的婴儿。这项研究的目的是确定稳定期早产儿过渡期后的RVO，LVO和SVC。方法：采用功能超声心动图在出生少于32周的稳定早产婴儿中，在其出生后第7天和第14天测量RVO，LVO和SVC流量，呼吸支持最少，无心血管支持。从数据收集后48小时内临床怀疑有感染或导管直径> 1.4 mm的婴儿被排除在分析之外。结果：我们对62名早产儿进行了111次测量，这些儿的中位（范围）胎龄为28（25-31）周，出生体重为1105（650-2370）g。在第7天和第14天分析了57个测量值。在第7天和433天，平均（SD）RVO，LVO和SVC流量分别为429（116），296（74）和89（33）ml / kg / min。第14天为81），300（79）和86（26）ml / kg / min，在配对测量中，第7天和第14天之间流量没有显着差异。结论：本研究提供了过渡期后稳定早产儿的中心血流值。流量变量显示在第7天到第14天之间保持稳定。
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