Identification of Four Additional Myoinhibitory Peptides (MIPs) From the Ventral Nerve Cord of Manduca sexta

摘要

four new myoinhibitory peptides were isolated and identified from the ventral nerve cord of adult Manduca sexta. The new peptides are related to two previously identified myoinhibitory peptides also isolated from adult M.sexta, Mas-MIP I and Mas-MIP II. The sequences for the new peptides are APEKWAAFHGSWamide (Mas-MIP III), GWNDMSSAWamide (Mas-MIP IV), (Mas-MIP VI). Mas-MIPs III-VI were found to inhibit spontaneous peristalsis of the adult M. sexta anterior inhibit spontaneous peristalsis of the adult M.sexta auterior hindgut (ileum) in vitro.