Inadvertent transplantation of haematopoietic stem cells carrying constitutional Robertsonian translocation from an apparently normal donor to an AML patient: a case report.

摘要

Robertsonian translocations (RTs) are relatively common constitutional cytogenetic abnormalities involving the acrocentric chromosomes 13, 14, 15, 21 and 22. In subjects in whom RTs occur, there are no overt clinical consequences. RTs can also rarely be discovered in tumour cells obtained from some haematological malignant cases. In such cases they are acquired cytogenetic aberrations and almost always result in a trisomic karyotype that could contribute to clonal evolution of the underlying neoplastic disease. We report a case of transplantation of haematopoietic stem cells (HSCs) bearing RTs from an apparently healthy BM donor to a recipient with AML.