Preparation of 1,2,4,5-tetrasubstituted imidazoles over magnetic core-shell titanium dioxide nanoparticles

摘要

Magnetic core-shell titanium dioxide nanoparticles (Fe3O4@SiO2@TiO2) were applied for the efficient preparation of 1,2,4,5-tetrasubstituted imidazole derivatives by the one-pot multi-component condensation of benzil with aldehydes, primary amines and ammonium acetate under solvent-free conditions. The catalyst was synthesized and studied using several techniques including X-ray diffraction, transmission electron microscopy, field-emission scanning electron microscopy and energy-dispersive X-ray spectroscopy. Copyright (c) 2016 John Wiley & Sons, Ltd.