Phosphine-Catalyzed Asymmetric [4+2] Annulation of Vinyl Ketones with Oxindole-Derived α,β-Unsaturated Imines: Enantioselective Syntheses of 2',3'-Dihydro-1'H-spiro[indoline-3,4'-pyridin] -2-ones

摘要

A novel asymmetric [4+2] annulation of vinyl ketones with oxindole-derived α,β-unsaturated imines has been developed in the presence of a multifunctional thiourea-phosphine catalyst derived from a natural amino acid, providing the first phos-phine-catalyzed enantioselective synthesis of 2',3'-dihydro-1'H-spiro[indoline-3,4'-pyridin]-2-ones in good yields with excellent stereoselectivities under mild conditions.