Organocatalytic Diels-Alder Reaction of 2-Vinylindoles with Methyleneindolinones: An Efficient Approach to Functionalized Carbazolespirooxindoles

摘要

An unprecedented asymmetric Diels-Alder reaction of 2-vinylindoles with methyleneindolinones has been disclosed. Under bifunctional organocatalysis by cinchona-derived squaramide catalyst, a series of diversely functionalized carbazolespiroox-indole derivatives bearing three contiguous stereo-centers are rapidly constructed under mild conditions (48-90% yields, up to > 20: 1 dr and 99% ee).