Chemical Composition and Pharmacological Activities of Plantago major L. in Vietnam

摘要

Plantago major L. in Vietnam was investigated for its chemical composition and also evaluated the biological activities against enzyme a-glucosidase and free radicals activities. The powder mixture of dried leave and roots of this species was extracted separately by three solvents: dichloromethane, water, watenalcohol (50:50, v:v). The chemical composition of dichloromethane exfract was analyzed by GC-MS system to identify eighteen components, out of which eight biologically active compounds viz. 5-hydroxymethylfurfural, n-hecxadecanoic acid, 9,12-octadecadienoic acid (Z,Z)-mefhyl ester, allogibberic acid, B-tocopherol, campesterol, y-sitosterol, lup-20(29)-en-3-ol and friedenlan-3-one were presented. The concentration of radical scavenging activity DPPH expressed by IC50 for water, watenalcohol (50:50, v:v) and dichloromethane with 208.7, 89.3 and 62.05 ug/mL, respectively. The dichloromethane, water and watenalcohol (50:50, v:v) extract of Plantago major exhibited a-glucosidase inhibitory activity with IC5o values of 116.4, 302.7, 195.9 ug/mL, respectively, which was comparable with acarbose (98.4 ug/mL). Plantago major h. in Vietnam may be effective inhibitors as the antidiabetic candidate and helpful to reduce the postprandial glucose levels.