Synthesis and Antimicrobial Evaluation of (1‐(2‐(Benzyloxy)‐2‐oxoethyl)‐1 HH ‐1,2,3‐triazol‐4‐yl)methyl Benzoate Analogues

摘要

> A convenient one pot synthesis of 20 (1‐(2‐(benzyloxy)‐2‐oxoethyl)‐1 H ‐1,2,3‐triazol‐4‐yl)methyl benzoate analogues ( 5a – 5t ) with ester functionality was carried out via Cu(I) catalyzed click reaction between prop‐2‐yn‐1‐yl benzoates and benzyl 2‐azidoacetates. The structure of synthesized triazoles were explicated by various spectral techniques like FT‐IR, 1 H NMR, 13 C NMR, and high‐resolution mass spectrometry and evaluated for in vitro antimicrobial potential against Staphylococcus aureus , Escherichia coli , Klebsiella pneumoniae , Enterobacter aerogenes , Candida albicans , and Aspergillus niger . Most of synthesized triazole derivatives exhibited average to excellent activity against tested microbial strains.