Determination of micelle/water partiton coefficients of cosmetic preservatives Optimisation of the capillary electrophoretic method

摘要

The hydorphobicity of a group of molecules used as preservatives for aqueous cosmetics,xontaining surfactants in the form of micelles,was evaluated by means of micellar electrokinetic capillary chromatography (MECC).Five different preservatives mixtures were examined,with a composition analogous to that employed in the preservation of cosmetic formulations.Sodiumdodecyl sulphate and sodium dodecyl(polyoxyethylene)_(1-4)sulphate were used as model surfactant and surfactant present in real cosmetic samples,respectively.The appropriate choice of the micellar velocity marker turned out to be a crucial point for the application of the MECC approach.