An Efficient and General Method for the Synthesis of alphe,omicron-Difunctional Reduced Polypropionates by Zr-Catalyzed Asymmetric Carboalumination: Synthesis of the Scyphostatin Side Chain

摘要

We recently reported an efficient and general method for the synthesis of reduced polypropionates with a single hetero-function through the application of Zr-catalyzed asymmetric carboalumination.In view of the large number of complex natural products that are of medicinal and biological interest,such as scyphostatin(1),ionomycin,doliculide,and borrelidin,we thought it worthwhile to search for a related method for the synthesis of terminally differentiated alpha,omicron-difunctional reduced polypropionates through the use of Zr-catalyzed asymmetric carboalumination.