Total Synthesis of (-)- and ent-(+)-Vindorosine: Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition of 1,3,4-Oxadiazoles

摘要

Vindorosine (1) is among the most complex, highly functionalized, and stereochemically rich natural products within a family of more than 90 alkaloids isolated from the Madagascan periwinkle (Catharanthus roseus (L.) G. Don).