Cardiac resynchronization therapy (CRT) can have a profound therapeutic impact on appropriately selected patients. However, even when the current clinical guidelines for CRT1 are rigorously applied, the response rate is ≈70%. Nearly a third of patients who undergo implantation of a CRT device are clinical nonresponders and more may be "remodeling nonresponders." An extensive body of literature reports on a wide variety of methods that can be better used to identify potential responders by measurement of mechanical dyssynchrony. Factors responsible for nonresponse include comorbid conditions, cardiac substrate, left ventricular (LV) lead location, and device programming. Comorbid conditions such as obstructive sleep apnea, right-sided heart failure, and type of intraventricular conduction delay should be considered at the preprocedural stage.
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机译：Cardiac resynchronization therapy (CRT) can have a profound therapeutic impact on appropriately selected patients. 然而，即使当施加严格的CRT1的当前临床指南时，响应速率也≈70％。 几乎三分之一的接近CRT装置的患者是临床无反应者，并且更多可能是“重塑无关的患者”。 关于各种方法的广泛的文献报告，可以更好地通过测量机械Dyssynchrony来识别潜在的响应者。 负责非响应的因素包括合并条件，心脏衬底，左心室（LV）铅位置和设备编程。 在预连体阶段应考虑诸如阻塞性睡眠呼吸暂停，右侧心力衰竭和腔内传导延迟类型的共用条件。
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