RUNX1 Deficiency Cooperates with SRSF2 Mutation to Further Disrupt RNA Splicing and Exacerbate Myelodysplastic Syndromes in Mouse Models

Huang Yi-Jou; Yan Ming; Chen Jia-Yu; Chen Liang; Kim Eunhee; Shima Takahiro; Davis Amanda G.; Miyauchi Sayuri; Stoner Samuel A.; Fu Xiang-Dong; Abdel-Wahab Omar I.; Zhang Dong-Er

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RUNX1 Deficiency Cooperates with SRSF2 Mutation to Further Disrupt RNA Splicing and Exacerbate Myelodysplastic Syndromes in Mouse Models

机译：RunX1缺乏与SRSF2突变合作，以进一步破坏小鼠模型中的RNA剪接和加剧肌小肌骨型综合征

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来源
《Blood: The Journal of the American Society of Hematology》 |2018年第novaelatreatmentappr期|共2页
作者
Huang Yi-Jou; Yan Ming; Chen Jia-Yu; Chen Liang; Kim Eunhee; Shima Takahiro; Davis Amanda G.; Miyauchi Sayuri; Stoner Samuel A.; Fu Xiang-Dong; Abdel-Wahab Omar I.; Zhang Dong-Er;
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作者单位

Univ Calif San Diego La Jolla CA 92093 USA;

Univ Calif San Diego La Jolla CA 92093 USA;

Univ Calif San Diego La Jolla CA 92093 USA;

Univ Calif San Diego La Jolla CA 92093 USA;

Ulsan Natl Inst Sci &

Technol Ulsan South Korea;

Univ Calif San Diego La Jolla CA 92093 USA;

Univ Calif San Diego La Jolla CA 92093 USA;

Univ Calif San Diego La Jolla CA 92093 USA;

Univ Calif San Diego La Jolla CA 92093 USA;

Univ Calif San Diego La Jolla CA 92093 USA;

Mem Sloan Kettering Canc Ctr Human Oncol &

Pathogenesis Program 1275 York Ave New York NY 10021;

Univ Calif San Diego La Jolla CA 92093 USA;

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原文格式 PDF
正文语种 eng
中图分类血液及淋巴系疾病;
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专利

1. 原位杂交检测pal-1 mRNA在秀丽小杆线虫野生型和突变体早期胚胎中的分布 [J] . 杨玉荣, 傅兴动物学报（英文版） . 2005,第005期
2. RUNX1 Deficiency Cooperates with SRSF2 Mutation to Further Disrupt RNA Splicing and Exacerbate Myelodysplastic Syndromes in Mouse Models [J] . Huang Yi-Jou, Yan Ming, Chen Jia-Yu, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：RunX1缺乏与SRSF2突变合作，以进一步破坏小鼠模型中的RNA剪接和加剧肌小肌骨型综合征
3. SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing [J] . Yukiko Komeno, Yi-Jou Huang, Jinsong Qiu, Molecular and Cellular Biology . 2015,第17期

机译：SRSF2是造血必不可少的，其骨髓增生异常综合征相关的突变失调替代前mRNA剪接。
4. Runx1 Deficiency and MDS-Associated U2af1 Mutation Cooperate for Leukemia Development in a New Mouse Model [J] . Zhen Tao, Fei Dennis Liang, Zhao Ling, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：Runx1缺乏症和MDS相关的U2af1突变合作为新的小鼠模型中的白血病发展。
5. Ras gene mutation in acute myeloid leukemia and Myelodysplastic syndromes: a meta-analysis of its occurrence and prognostic relevance [C] . Cheng Jingru, Wang Peng, Zhang Tai, International Conference on Advanced Materials and Computer Science . 2016

机译：RAS基因突变在急性髓性白血病和髓细胞增强综合征中：荟萃分析其发生和预后相关性
6. Characterization of the Myelodysplastic Syndromes-Related SRSF2 P95 Mutation. [D] . Skrdlant, Lindsey. 2016

机译：骨髓增生异常综合征相关的SRSF2 P95突变的表征。
7. SRSF2 Is Essential for Hematopoiesis and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing [O] . Yukiko Komeno, Yi-Jou Huang, Jinsong Qiu, 2015

机译：SRSF2是造血必不可少的其骨髓增生异常综合征相关的突变失调替代前mRNA剪接。
8. SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing [O] . Yukiko Komeno, Yi-Jou Huang, Jinsong Qiu, 2015

机译：SRSF2对于血缺乏症是必不可少的，其骨髓性增生综合征相关的突变能够进行调节替代的前mRNA拼接

RUNX1 Deficiency Cooperates with SRSF2 Mutation to Further Disrupt RNA Splicing and Exacerbate Myelodysplastic Syndromes in Mouse Models

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