Efficient synthesis of both diastereomers of beta,gamma-diamino acids from phenylalanine and tryptophan

摘要

We synthesized in a few steps both diastereomers of orthogonally protected beta,gamma-diamino acids starting from l-phenylalanine or l-tryptophan. These final compounds are interesting building blocks for peptide synthesis and foldamer chemistry. The key step is a Blaise reaction performed under ultrasound conditions.