[~(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor

Ian M. Bell; Steven N. Gallicchio; Craig A. Stump

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[~(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor

机译：[〜（11）C] MK-4232：降钙素基因相关肽受体的第一个正电子发射断层显像示踪剂

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Rational modification of the potent calcitonin gene-related peptide (CGRP) receptor antagonist MK-3207 led to a series of analogues with enhanced CNS penetrance and a convenient chemical handle for introduction of a radiolabel. A number of 11C-tracers were synthesized and evaluated in vivo, leading to the identification of [11C]8 ([11C]MK-4232), the first positron emission tomography tracer for the CGRP receptor.

机译：降钙素基因相关肽（CGRP）受体有效拮抗剂MK-3207的合理修饰，导致了一系列具有增强的CNS渗透性的类似物，并为引入放射性标记提供了方便的化学方法。合成了多种11C示踪剂，并在体内进行了评估，从而鉴定出[11C] 8（[11C] MK-4232），这是CGRP受体的第一个正电子发射断层显像剂。

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《ACS medicinal chemistry letters》 |2013年第9期|共6页
作者
Ian M. Bell; Steven N. Gallicchio; Craig A. Stump;
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正文语种 eng
中图分类药学;化学;
关键词
MK-4232; calcitonin gene-related peptide receptor; positron emission tomography;

机译：MK-4232;降钙素基因相关肽受体;正电子发射断层扫描;

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1. [~(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor [J] . Ian M. Bell, Steven N. Gallicchio, Craig A. Stump ACS medicinal chemistry letters . 2013,第9期

机译：[〜（11）C] MK-4232：降钙素基因相关肽受体的第一个正电子发射断层显像示踪剂
2. Quantitative autoradiography with short-lived positron emission tomography tracers: a study on muscarinic acetylcholine receptors with N-((11)C)methyl-4-piperidylbenzilate. [J] . Sihver S, Sihver W, Bergstrom M, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 1999,第2期

机译：带有短寿命正电子发射断层扫描示踪剂的定量放射自显影：N-（（（11）C）methyl-4-piperidylbenzilate）对毒蕈碱乙酰胆碱受体的研究。
3. Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [~(11)C]SNAP-7941 and [~(18)F]FE@SNAP for Positron Emission Tomography [J] . Eva Schirmer, Karem Shanab, Barbara Datterl Molecules . 2013,第10期

机译：黑色素浓缩激素受体1（MCHR1）示踪剂[〜（11）C] SNAP-7941和[〜（18）F] FE @ SNAP的正电子发射层析成像的前体和参考化合物的合成
4. Assessment of natriuretic peptide clearance receptor with positron emission tomography in cardiovascular disease models [C] . Liu Y., Rossin R., Abendschein D., Computers in Cardiology, 2009 . 2009

机译：正电子发射断层扫描在心血管疾病模型中评估利钠肽清除受体的作用
5. Pre-clinical evaluation of [carbon-11]-(+)-PHNO as an agonist positron emission tomography (PET) radiotracer for imaging of the high-affinity state of the dopamine D2 receptor. [D] . McCormick, Patrick Neil. 2006

机译：临床前评估[碳11]-（+）-PHNO作为激动剂正电子发射断层扫描（PET）示踪剂，用于对多巴胺D2受体的高亲和力状态进行成像。
6. 11CMK-4232: The First Positron EmissionTomography Tracer for the Calcitonin Gene-Related Peptide Receptor [O] . Ian M. Bell, *, StevenN. Gallicchio, 2013

机译：11C MK-4232：第一个正电子发射降钙素基因相关肽受体的断层扫描示踪剂
7. Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography [O] . Cécile Philippe, Wolfgang Wadsak, Catharina Neudorfer, 2013

机译：用于正电子发射断层扫描的黑色素浓集激素受体1（mCHR1）示踪剂[11C] sNap-7941和[18F] FE @ sNap的前体和参考化合物的合成

[~(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor

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