Intima-media Thickness and Arteriosclerotic Risk Factors in Elderly Dyslipidemic Patients with and without Hypertension on Statin Therapy-IMT and Elderly Dyslipidemia-

摘要

The associations between intima-media thickness of the carotid arteries (IMT) and dyslipidemia in elderly patients with and without hypertension (HT), with both groups on statin therapy, were examined in order to inform medical staff of the importance of the medical care of hypertensive patients with dyslipidemia. A cross-sectional analysis of 71 elderly patients (male/female ：15/56， mean age ： 73.8 +- 9.0 years) on statin therapy for dyslipidemia was performed. Of these, 37 patients (male/female ： 9/28， mean age ： 70.6 +-10.1 years) were not hypertensive, and the remaining 34 (6/28, and 77.2 +-6.1 respectively) were on antihypertensive medications. Arteriosclerotic risk factors examined included type 2 diabetes mellitus, ischemic heart disease, cerebrovascular disorder, body mass index (BMI), sex, age, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HLD-C), non-HDL-C, LDL-C/HDL-C ratio (LH ratio), total cholesterol (TC), and triglycerides (TG). Statistical analysis was performed using the unpaired t-test to compare IMT between the non-HT group and the HT group, and the associations between IMT and arteriosclerotic risk factors in the non-HT and HT groups. It was found that, though there was no significant difference in IMT between the non-HT and HT groups, IMT was thicker in the HT group than in the non-HT group, and IMT was significantly affected only by age in the non-HT group, whereas it was significantly affected by type 2 diabetes mellitus, cerebrovascular disorder, TC, LDL-C, non-HDL-C, and the LH ratio in the HT group. Considering the significant differences in the risk factors between the non-HT and HT groups, it is necessary to pay more attention to preventing and treating arteriosclerosis in patients with HT. Early identification of this difference by regular health checks could facilitate early prevention and treatment. This study demonstrated that follow-up of HT patients may well include statin therapy, HT treatment, IMT measurement, obesity management and consideration of the risk factors (type 2 diabetes mellitus, cerebrovascular disorder, TC, LDL-C, non-HDL-C, and LH ratio).