ONLINE FEATURES Observations on Nanotechnology-based Drug Delivery Approaches: Translating Nanotechnology from Bench to Pharmaceutical Market: Barriers, Success, and Promises

摘要

To stay competitive in today's challenging business environment, drug delivery technologies are needed that offer positive differentiation over first-generation commercial products [1, 2]. In formulations intended for oral administration, poorly water-soluble APIs, classified according to the Biopharmaceutical Classification System as Class II (BCS class II), may suffer from an inadequate, or highly variable, rate and/or extent of drug absorption (sometimes as a function of food in the stomach, i.e., fed/fasted variability).