Incidence and prevalence of hepatitis B in patients with diabetes mellitus in the UK UK : A population‐based cohort study using the UK UK Clinical Practice Research Datalink

摘要

Summary We assessed the incidence and prevalence of hepatitis B (Hep B) in patients with or without diabetes mellitus (DM) using the UK Clinical Practice Research Datalink (CPRD). This was a retrospective, observational study of diabetic and nondiabetic cohorts aged 0‐80?years using CPRD ( NCT 02324218). Incidence rates ( IR ) for each cohort were calculated. Crude and adjusted (Poisson regression) IR ratios ( IRR ) were estimated with 95% confidence intervals ( CI ) to compare the cohorts. Hep B prevalence stratified by age, and hospitalization related to Hep B was also calculated. Of 7?712?043 subjects identified, 4?839?770 were included (DM: 160?760; non‐DM: 4?679?010). Mean ages were 54.4 and 32.0?years, and 57.20% and 50.14% were male in the diabetic and nondiabetic cohorts, respectively. Hep B was identified in 29 diabetic and 845 nondiabetic subjects; IR was 4.03 per 100?000 person‐years and 2.88 per 100?000 person‐years, respectively. The adjusted IRR was 1.00 (95% CI : 0.70‐1.50) between diabetic and nondiabetic cohorts. Hep B prevalence was higher in the diabetic cohort (0.01%‐0.26%) than in the nondiabetic cohort (0.00%‐0.03%) across the different age groups. Hep B‐associated hospitalization IR was higher in the diabetic cohort (4.98‐10.91) than the nondiabetic cohort (0.26‐2.44). The Hep B IR , hospitalization and prevalence were higher in males in both cohorts. In conclusion, the risk of incident Hep B diagnosis in the diabetic cohort was not different from that in the nondiabetic cohort. However, prevalence of Hep B and Hep B‐associated hospitalization rate was higher in the diabetic than in the nondiabetic cohort.