Prostaglandin E-2: A Pancreatic Fluid Biomarker of Intraductal Papillary Mucinous Neoplasm Dysplasia

摘要

BACKGROUND: With the increased frequency of diagnostic imaging, pancreatic cysts are now detected in > 3% of American adults. Most of these are intraductal papillary mucinous neoplasms (IPMNs) with well-established but variable malignant potential. A biomarker that predicts malignant potential or dysplastic grade would help determine which IPMNs require removal and which can be observed safely. We previously reported that pancreatic fluid prostaglandin E-2 (PGE(2)) levels might have promise as a predictor of IPMN dysplasia and we seek to validate those results in the current study.