Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma

Rodriguez Erika Gonzalez; Ostrowski Sisse R.; Cardenas Jessica C.; Baer Lisa A.; Tomasek Jeffrey S.; Henriksen Hanne H.; Stensballe Jakob; Cotton Bryan A.; Holcomb John B.; Johansson Par I.; Wade Charles E.

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Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma

机译：Syndecan-1：创伤内皮病的定量标志物

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BACKGROUND: Endothelial glycocalyx breakdown elicits syndecan-1 shedding and endotheliopathy of trauma (EoT). We hypothesized that a cutoff syndecan-1 level can identify patients with endothelial dysfunction who would have poorer outcomes.

机译：背景：内皮血糖含有颗粒细胞突发出来Syndecan-1脱落和创伤的内皮病变。我们假设截止截止综合征-1水平可以识别内皮功能障碍的患者，该功能障碍将具有较差的结果。

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来源
《Journal of the American College of Surgeons》 |2017年第3期|共9页
作者
Rodriguez Erika Gonzalez; Ostrowski Sisse R.; Cardenas Jessica C.; Baer Lisa A.; Tomasek Jeffrey S.; Henriksen Hanne H.; Stensballe Jakob; Cotton Bryan A.; Holcomb John B.; Johansson Par I.; Wade Charles E.;
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Univ Texas Hlth Sci Ctr Houston UT Hlth Ctr Translat Injury Res Dept Surg Houston TX 77030 USA;

Copenhagen Univ Hosp Rigshosp Sect Transfus Med Capital Reg Blood Bank Copenhagen Denmark;

Univ Texas Hlth Sci Ctr Houston UT Hlth Ctr Translat Injury Res Dept Surg Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston UT Hlth Ctr Translat Injury Res Dept Surg Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston UT Hlth Ctr Translat Injury Res Dept Surg Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston UT Hlth Ctr Translat Injury Res Dept Surg Houston TX 77030 USA;

Copenhagen Univ Hosp Rigshosp Sect Transfus Med Capital Reg Blood Bank Copenhagen Denmark;

Univ Texas Hlth Sci Ctr Houston UT Hlth Ctr Translat Injury Res Dept Surg Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston UT Hlth Ctr Translat Injury Res Dept Surg Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston UT Hlth Ctr Translat Injury Res Dept Surg Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston UT Hlth Ctr Translat Injury Res Dept Surg Houston TX 77030 USA;

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正文语种 eng
中图分类外科学;
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专利

1. Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma [J] . Rodriguez Erika Gonzalez, Ostrowski Sisse R., Cardenas Jessica C., Journal of the American College of Surgeons . 2017,第3期

机译：Syndecan-1：创伤内皮病的定量标志物
2. Microfluidics: A high-throughput system for the assessment of the endotheliopathy of trauma and the effect of timing of plasma administration on ameliorating shock-associated endothelial dysfunction [J] . Diebel Lawrence N., Martin Jonathan V., Liberati David M. The journal of trauma and acute care surgery . 2018,第4期

机译：微流体：用于评估创伤内皮病的高通量系统以及血浆给药时序对改善冲击相关内皮功能障碍的影响
3. Sympathoadrenal activation and endotheliopathy are drivers of hypocoagulability and hyperfibrinolysis in trauma: A prospective observational study of 404 severely injured patients [J] . Ostrowski Sisse R., Henriksen Hanne H., Stensballe Jakob, The journal of trauma and acute care surgery . 2017,第2期

机译：Sympathnadrenal激活和内皮病是创伤中的低磁性和Hypercibrinolys的驱动因素：404名严重受伤患者的前瞻性观察研究
4. Determining early markers of disease using Raman spectroscopy in a rat combat-trauma model of heterotopic ossification [C] . Katherine E. Cilwa, Ammar T. Qureshi, Jonathan A. Forsberg, Photonic therapeutics and diagnostics XII . 2016

机译：在异位骨化的大鼠战斗创伤模型中使用拉曼光谱法确定疾病的早期标记
5. Psychophysiological Markers of Trauma: Investigating the Absence of Vagal Brake in Veterans with a History of Interpersonal Trauma [D] . Guiles, Robert Arthur Farrior 2019

机译：创伤的心理生理学标志：调查具有人际创伤史的退伍军人的迷走神经制动
6. Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study [O] . David N. Naumann, Jon Hazeldine, Robert J. Dinsdale, 2011

机译：严重创伤后，内皮病与较高水平的无细胞DNA相关：前瞻性观察研究
7. Endotheliopathy of Trauma is an on-Scene Phenomenon, and is Associated with Multiple Organ Dysfunction Syndrome: A Prospective Observational Study [O] . David N. Naumann, Jon Hazeldine, David J. Davies, 2018

机译：创伤的内皮病是一个现场现象，与多器官功能障碍综合征有关：一项潜在的观察研究

Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma

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