Lack of Association Between Interleukin 28B Polymorphism and Vertical Transmission of Hepatitis C

Einberg Afrodite Psaros; Duberg Ann-Sofi; Filipovich Olga; Nystrom Jessica; Zhirkov Anton; Brenndorfer Erwin D.; Frelin Lars; Rukoiatkina Elena; Lobzin Yuriy; Sallberg Matti; Fischler Bjorn; Lutckii Anton

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Lack of Association Between Interleukin 28B Polymorphism and Vertical Transmission of Hepatitis C

机译：白细胞介素28b多态性与丙型肝炎垂直传播之间的关联缺乏关联

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Objectives: Single genetic nucleotide polymorphism (rs12979860) near the gene for interleukin 28B (IL28B) is known to be of importance for frequency of spontaneous clearance and treatment outcome in interferon-based therapies in patients with hepatitis C virus (HCV) infection. The aim of the present study was to investigate whether IL28B polymorphism in children and/or their mothers plays a role in vertical transmission of HCV (HCV-VT).

机译：目的：已知在白细胞介素28b（IL28b）的基因附近的单遗传核苷酸多态性（RS12979860）是对乙型肝炎病毒（HCV）感染患者的干扰素疗法中自发清除和治疗结果的频率的重要性。本研究的目的是调查儿童和/或其母亲的IL28B多态性是否在HCV（HCV-VT）的垂直传播中起作用。

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来源
《Journal of pediatric gastroenterology and nutrition》 |2017年第6期|共5页
作者
Einberg Afrodite Psaros; Duberg Ann-Sofi; Filipovich Olga; Nystrom Jessica; Zhirkov Anton; Brenndorfer Erwin D.; Frelin Lars; Rukoiatkina Elena; Lobzin Yuriy; Sallberg Matti; Fischler Bjorn; Lutckii Anton;
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作者单位

Karolinska Inst Dept Clin Sci Intervent &

Technol CLINTEC Stockholm Sweden;

Orebro Univ Fac Med &

Hlth Dept Infect Dis Orebro Sweden;

North Western State Med Univ St Petersburg Russia;

Karolinska Inst Dept Lab Med Div Clin Microbiol Stockholm Sweden;

St Petersburg State Pediat Med Univ Sci Res Inst Childrens Infect St Petersburg Russia;

Karolinska Inst Dept Lab Med Div Clin Microbiol Stockholm Sweden;

Karolinska Inst Dept Lab Med Div Clin Microbiol Stockholm Sweden;

St Petersburg State Pediat Med Univ Matern Hosp 16 St Petersburg Russia;

St Petersburg State Pediat Med Univ Sci Res Inst Childrens Infect St Petersburg Russia;

Karolinska Inst Dept Lab Med Div Clin Microbiol Stockholm Sweden;

Karolinska Inst Dept Clin Sci Intervent &

Technol CLINTEC Stockholm Sweden;

Karolinska Inst Dept Lab Med Div Clin Microbiol Stockholm Sweden;

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原文格式 PDF
正文语种 eng
中图分类儿科学;
关键词
hepatitis C virus; hepatitis C; interleukin 28B single genetic nucleotide polymorphism; mother-to-child-transmission; perinatal transmission;

机译：丙型肝炎病毒;丙型肝炎;白细胞介素28b单遗传核苷酸多态性;母为儿童传播;围产期传播;

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专利

1. Lack of Association Between Interleukin 28B Polymorphism and Vertical Transmission of Hepatitis C [J] . Einberg Afrodite Psaros, Duberg Ann-Sofi, Filipovich Olga, Journal of pediatric gastroenterology and nutrition . 2017,第6期

机译：白细胞介素28b多态性与丙型肝炎垂直传播之间的关联缺乏关联
2. Lack of association between interleukin 28B polymorphisms and spontaneous viral clearance in hepatitis B virus patients [J] . LiaoY., LiY., CaiB., Clinical infectious diseases . 2013,第4期

机译：乙型肝炎病毒患者白细胞介素28B多态性与自发病毒清除率之间缺乏关联
3. Lack of association between interleukin 28B polymorphisms and spontaneous viral clearance in hepatitis B virus patients [J] . LiaoY., LiY., CaiB., Clinical infectious diseases . 2013,第4期

机译：白细胞介素28b多态性与乙型肝炎病毒患者的自发病毒间隙之间缺乏关联
4. ASSOCIATION OF ESTROGEN RECEPTOR A GENE POLYMORPHISMS WITH HEPATITIS C VIRUS (HCV)-RELATED LIVER DISCASE [C] . Yang Jingjing, Zhang Yun, Wang Haopeng, The 6'th International Forum on Post-genome Technologies(6'IFPT)（第六届国际后基因组生命科学技术学术论坛） . 2009

机译：雌激素受体基因多态性与丙型肝炎病毒（HCV）相关的肝脏疾病的关联
5. Hepatitis B and C infections, single nucleotide polymorphisms of the inflammatory pathway, and the risk of non-Hodgkin's lymphoma. [D] . Ng, Leslie J. 2008

机译：乙型和丙型肝炎感染，炎性途径的单核苷酸多态性以及非霍奇金淋巴瘤的风险。
6. Lack of association between interleukin 28B gene polymorphisms (rs8099917G/T rs12979860 C/T) and susceptibility to chronic hepatitis C virus infection Tehran Iran [O] . Maryam Karkhane, Seyed Reza Mohebbi, Pedram Azimzadeh, 2016

机译：白细胞介素28B基因多态性（rs8099917G / Trs12979860 C / T）与慢性丙型肝炎病毒易感性之间缺乏关联伊朗德黑兰
7. Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response [O] . P. J. Clark, A. J. Thompson, M. Zhu, 2012

机译：白细胞介素28b多态性是与基因型-1慢性丙型肝炎的低密度脂蛋白胆固醇（LDL-C）相关的唯一常见的遗传变体，并确定LDL-C与治疗反应之间的关联
8. Lack of an Autosomal Recessive Genetic Influence in Vertical Transmission of Hepatitis B Antigen. [R] . Stevens, C. E., Beasley, R. P. 1975

机译：缺乏常染色体隐性遗传对乙型肝炎抗原垂直传播的影响。

Lack of Association Between Interleukin 28B Polymorphism and Vertical Transmission of Hepatitis C

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