In Vitro Fertilization Success Rates after Surgically Treated Endometriosis and Effect of Time Interval between Surgery and In Vitro Fertilization

摘要

Abstract Study Objective To evaluate the impact of endometriosis staging and endometriomas on in vitro fertilization (IVF) outcome and to assess the optimal time interval between laparoscopy and IVF. Design A retrospective clinical study (Canadian Task Force classification II1). Setting A university-affiliated private infertility clinic. Patients Two hundred sixteen infertile patients with endometriosis and 209 infertile patients without endometriosis. Interventions Laparoscopy, IVF. Measurements and Main Results: Patients with endometriosis were classified according to American Society for Reproductive Medicine criteria; 58, 67, 63, and 28 patients had stages 1 through 4 disease, respectively. Patients with endometriosis had significantly lower estradiol on trigger day (9986?±?6710 vs 12 220?±?9414?pg/mL, respectively) and number of retrieved oocytes (12.7?±?8.6 vs 14.0?±?10, respectively) compared with controls. We found a consistent decline in clinical and ongoing pregnancy rates with increasing stage of endometriosis. The presence of endometrioma in patients with stages 3 and 4 endometriosis did not alter IVF outcome. Patients with a time interval of 7 to 12 and 13 to 25 months after surgery had a favorable outcome. Conclusion IVF pregnancy rate was negatively correlated with endometriosis severity. The presence of endometriomas had no impact on IVF clinical outcome. The optimal time to perform IVF appears to be between 7 and 25 months after endometriosis surgery.