Are calcium channel blockers (CCBs) effective therapy for Raynaud phenomenon? CCBs are modestly effective at reducing the frequency of attacks of primary Raynaud phenomenon. There is no evidence that attack severity or physiologic measurements are reduced by CCBs. Treatment is associated with adverse effects such as headache, flushing, and edema. (Strength of Recommendation: B, based on inconsistent or limited-quality patient-oriented evidence.)
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