Antibody nanotechnology mediated by site-specific assembly enhances antitumor efficacy of therapeutic antibodies via multivalent binding

Zhao Ying; Gao Liquan; Wang Fan; Nie Guangjun

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Antibody nanotechnology mediated by site-specific assembly enhances antitumor efficacy of therapeutic antibodies via multivalent binding

机译：由位点特异性组装介导的抗体纳米技术可通过多价结合增强治疗性抗体的抗肿瘤功效

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来源
《Journal of Labelled Compounds and Radiopharmaceuticals》 |2019年第s1期|共1页
作者
Zhao Ying; Gao Liquan; Wang Fan; Nie Guangjun;
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作者单位

Natl Ctr Nanosci &

Technol Beijing Peoples R China;

Peking Univ Beijing Peoples R China;

Peking Univ Beijing Peoples R China;

Natl Ctr Nanosci &

Technol Beijing Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药学;
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1. Antibody nanotechnology mediated by site-specific assembly enhances antitumor efficacy of therapeutic antibodies via multivalent binding [J] . Zhao Ying, Gao Liquan, Wang Fan, Journal of Labelled Compounds and Radiopharmaceuticals . 2019,第S1期

机译：由位点特异性组装介导的抗体纳米技术可通过多价结合增强治疗性抗体的抗肿瘤功效
2. Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy [J] . Haitao Pan, Jiayu Liu, Wentong Deng, International Journal of Nanomedicine . 2018,第3期

机译：抗CEA / CD3双特异性抗体的位点特异性PEG化可改善其抗肿瘤功效
3. Antibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma [J] . Freimark Bruce D., Gong Jian, Ye Dan, Cancer immunology research. . 2016,第6期

机译：抗体介导的磷脂酰丝氨酸阻断增强了黑色素瘤对CTLA-4和PD-1抗体的抗肿瘤反应。
4. Nanoparticles Coated with Frizzled7 Antibodies Enable Multivalent Binding for Enhanced Wnt Signaling Inhibition in Triple-Negative Breast Cancer [C] . Rachel S. Riley, Emily S. Day Society for Biomaterials annual meeting and exposition . 2018

机译：纳米颗粒涂有Frizzled7抗体使三价乳腺癌中增强Wnt信号抑制的多价结合。
5. The Site-specific Modification of Therapeutic Proteins Produced in Escherichia coli: Implementation of a Combinatorial Bispecific Antibody Fragment Library Against Human Breast Carcinomas. [D] . Isett, Kevin D. 2010

机译：大肠杆菌中产生的治疗性蛋白质的位点特异性修饰：针对人类乳腺癌的组合双特异性抗体片段文库的实现。
6. TMIC-42. TOCA 511 AND 5-FC INDUCES T CELL-MEDIATED ANTITUMOR IMMUNITY IN A MOUSE GLIOMA MODEL WHICH IS ENHANCED BY THE ADDITION OF A THERAPEUTIC ANTIBODY AGAINST CTLA-4 AND CORRELATIVE WITH A REDUCTION IN MEMORY T REGULATORY CELLS. [O] . Douglas Jolly, Leah Mitchell, Kader Yagiz, 2017

机译：TMIC-42。 TOCA 511和5-FC在小鼠胶质瘤模型中诱导T细胞介导的免疫反应该模型通过添加针对CTLA-4的治疗性抗体和与记忆性T调节性细胞减少相关联。
7. Therapeutic efficacy of antibodies lacking Fcγ receptor binding against lethal dengue virus infection is due to neutralizing potency and blocking of enhancing antibodies [corrected]. [O] . Katherine L Williams, Soila Sukupolvi-Petty, Martina Beltramello, 2013

机译：缺乏Fcγ受体结合针对致死性登革病毒感染的抗体的治疗功效是由于中和效力和阻断增强抗体[校正]。
8. Different Patterns of Inositol Polyphosphate Production Are Seen in B Lymphocytes after Cross-Linking of sIg by Anti-Ig Antibody or by a Multivalent Anti-Ig Antibody Dextran Conjugate. [R] . Brunswick, M., June, C. H., Finkelman, F. D., 1989

机译：在通过抗Ig抗体或多价抗Ig抗体葡聚糖缀合物交联sIg后，在B淋巴细胞中观察到不同模式的肌醇多磷酸盐产生。

Antibody nanotechnology mediated by site-specific assembly enhances antitumor efficacy of therapeutic antibodies via multivalent binding

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