Host conditioning and rejection monitoring in hepatocyte transplantation in humans

Soltys Kyle A.; Setoyama Kentaro; Tafaleng Edgar N.; Gutierrez Alejandro Soto; Fong Jason; Fukumitsu Ken; Nishikawa Taichiro; Nagaya Masaki; Sada Rachel; Haberman Kimberly; Gramignoli Roberto; Dorko Kenneth; Tahan Veysel; Dreyzin Alexandra; Baskin Kevin; Crowley John J.; Quader Mubina A.; Deutsch Melvin; Ashokkumar Chethan; Shneider Benjamin L.; Squires Robert H.; Ranganathan Sarangarajan; Reyes-Mugica Miguel; Dobrowolski Steven F.; Mazariegos George; Elango Rajavel; Stolz Donna B.; Strom Stephen C.; Vockley Gerard; Roy-Chowdhury Jayanta; Cascalho Marilia; Guha Chandan; Sindhi Rakesh; Platt Jeffrey L.; Fox Ira J.

首页> 外文期刊>Journal of Hepatology: The Journal of the European Association for the Study of the Liver >Host conditioning and rejection monitoring in hepatocyte transplantation in humans

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Host conditioning and rejection monitoring in hepatocyte transplantation in humans

机译：人类肝细胞移植中的宿主调理和排斥监测

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Background & Aims: Hepatocyte transplantation partially corrects genetic disorders and has been associated anecdotally with reversal of acute liver failure. Monitoring for graft function and rejection has been difficult, and has contributed to limited graft survival. Here we aimed to use preparative liver-directed radiation therapy, and continuous monitoring for possible rejection in an attempt to overcome these limitations.

机译：背景和目的：肝细胞移植部分校正遗传紊乱，并随着急性肝衰竭的逆转而与逆转症状相关。对移植物功能和拒绝的监测很困难，并且有助于有限的移植物存活。在这里，我们旨在使用制备肝脏定向的放射治疗，并持续监测可能的拒绝，以克服这些限制。

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来源
《Journal of Hepatology: The Journal of the European Association for the Study of the Liver》 |2017年第5期|共14页
作者
Soltys Kyle A.; Setoyama Kentaro; Tafaleng Edgar N.; Gutierrez Alejandro Soto; Fong Jason; Fukumitsu Ken; Nishikawa Taichiro; Nagaya Masaki; Sada Rachel; Haberman Kimberly; Gramignoli Roberto; Dorko Kenneth; Tahan Veysel; Dreyzin Alexandra; Baskin Kevin; Crowley John J.; Quader Mubina A.; Deutsch Melvin; Ashokkumar Chethan; Shneider Benjamin L.; Squires Robert H.; Ranganathan Sarangarajan; Reyes-Mugica Miguel; Dobrowolski Steven F.; Mazariegos George; Elango Rajavel; Stolz Donna B.; Strom Stephen C.; Vockley Gerard; Roy-Chowdhury Jayanta; Cascalho Marilia; Guha Chandan; Sindhi Rakesh; Platt Jeffrey L.; Fox Ira J.;
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作者单位

UPMC Childrens Hosp Pittsburgh Thomas E Starzl Transplant Inst 4401 Penn Ave Pittsburgh PA;

Univ Pittsburgh Sch Med Dept Surg Pittsburgh PA USA;

Univ Pittsburgh Sch Med Dept Surg Pittsburgh PA USA;

Univ Pittsburgh Sch Med Dept Pathol Pittsburgh PA USA;

Univ Pittsburgh Sch Med Dept Surg Pittsburgh PA USA;

Univ Pittsburgh Sch Med Dept Pathol Pittsburgh PA USA;

Univ Pittsburgh Sch Med Dept Surg Pittsburgh PA USA;

Univ Pittsburgh Sch Med Dept Surg Pittsburgh PA USA;

UPMC Childrens Hosp Pittsburgh Thomas E Starzl Transplant Inst 4401 Penn Ave Pittsburgh PA;

UPMC Childrens Hosp Pittsburgh Thomas E Starzl Transplant Inst 4401 Penn Ave Pittsburgh PA;

Karolinska Inst Dept Lab Med Div Pathol Stockholm Sweden;

Univ Pittsburgh Sch Med Dept Pathol Pittsburgh PA USA;

Univ Pittsburgh Sch Med Dept Pathol Pittsburgh PA USA;

Univ Pittsburgh Sch Med Dept Surg Pittsburgh PA USA;

UPMC Childrens Hosp Pittsburgh Div Vasc &

Intervent Radiol 4401 Penn Ave Pittsburgh PA 15224;

UPMC Childrens Hosp Pittsburgh Div Vasc &

Intervent Radiol 4401 Penn Ave Pittsburgh PA 15224;

Univ Pittsburgh Sch Med Dept Radiat Oncol Pittsburgh PA USA;

Univ Pittsburgh Sch Med Dept Radiat Oncol Pittsburgh PA USA;

UPMC Childrens Hosp Pittsburgh Thomas E Starzl Transplant Inst 4401 Penn Ave Pittsburgh PA;

UPMC Childrens Hosp Pittsburgh Div Pediat Gastroenterol Hepatol &

Nutr 4401 Penn Ave Pittsburgh;

UPMC Childrens Hosp Pittsburgh Div Pediat Gastroenterol Hepatol &

Nutr 4401 Penn Ave Pittsburgh;

UPMC Childrens Hosp Pittsburgh Dept Pathol 4401 Penn Ave Pittsburgh PA 15224 USA;

UPMC Childrens Hosp Pittsburgh Dept Pathol 4401 Penn Ave Pittsburgh PA 15224 USA;

UPMC Childrens Hosp Pittsburgh Dept Pathol 4401 Penn Ave Pittsburgh PA 15224 USA;

UPMC Childrens Hosp Pittsburgh Thomas E Starzl Transplant Inst 4401 Penn Ave Pittsburgh PA;

Univ British Columbia Dept Pediat Vancouver BC Canada;

Univ Pittsburgh Sch Med McGowan Inst Regenerat Med Pittsburgh PA USA;

Karolinska Inst Dept Lab Med Div Pathol Stockholm Sweden;

Univ Pittsburgh Sch Med Dept Pediat Pittsburgh PA 15261 USA;

Albert Einstein Coll Med Dept Med Bronx NY 10467 USA;

Univ Michigan Dept Surg Ann Arbor MI 48109 USA;

Albert Einstein Coll Med Dept Radiat Oncol Bronx NY 10467 USA;

UPMC Childrens Hosp Pittsburgh Thomas E Starzl Transplant Inst 4401 Penn Ave Pittsburgh PA;

Univ Michigan Dept Surg Ann Arbor MI 48109 USA;

UPMC Childrens Hosp Pittsburgh Thomas E Starzl Transplant Inst 4401 Penn Ave Pittsburgh PA;

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
Hepatocyte transplantation; Liver-based metabolic disease; Liver-directed radiation therapy; Phenylketonuria; Rejection risk monitoring; Hepatocyte xenotransplantation;

机译：肝细胞移植;肝脏代谢疾病;肝脏引导的放射疗法;苯丙酮尿;排斥风险监测;肝细胞异种持续;

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专利

1. Host conditioning and rejection monitoring in hepatocyte transplantation in humans [J] . Soltys Kyle A., Setoyama Kentaro, Tafaleng Edgar N., Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2017,第5期

机译：人类肝细胞移植中的宿主调理和排斥监测
2. Sialyl Lewis(x) (CD15s) monitoring as a means to select antirejection therapy in patients with rejection after renal transplantation: CD15s monitoring for treatment and diagnosis in patients with acute rejection after renal transplantation. [J] . Ishida H, Koyama I, Sawada T, Transplantation: Official Journal of the Transplantation Society . 2000,第10期

机译：监测唾液酸化路易斯（x）（CD15s）作为选择肾移植后排斥反应患者抗排斥疗法的一种手段：监测CD15s监测肾移植后急性排斥反应患者的治疗和诊断。
3. Critical role of natural killer cells in the rejection of human hepatocytes after xenotransplantation into immunodeficient mice. [J] . Kawahara T, Douglas DN, Lewis J, Transplant international : . 2010,第9期

机译：天然杀伤细胞在异种移植到免疫缺陷小鼠中后在人类肝细胞排斥中的关键作用。
4. Repopulation of diseased mouse liver with rodent and human adult primary hepatocytes and long-term survival of transplanted hepatocytes in the uPA/RAG-2 mouse model [C] . M. DANDRI, M. R. BURDA, J. PETERSEN, International Congress on Thrombosis . 2002

机译：用啮齿动物和人成人原发性肝细胞的患病小鼠肝脏的重新迁移，upA / Rag-2小鼠模型中移植肝细胞的长期存活
5. The Role of Human Leukocyte Antigen-G and Its Polymorphisms in Post-transplant Malignancy and Acute Rejection following Heart Transplantation [D] . Adamson, Mitchell B. 2019

机译：人白细胞抗原-G的作用及其多态性在移植后的恶性肿瘤和急性排斥反应后心脏移植
6. Host conditioning and rejection monitoring in hepatocyte transplantation in humans [O] . Kyle A. Soltys, Kentaro Setoyama, Edgar N. Tafaleng, -1

机译：人体肝细胞移植中的宿主调节和排斥监测
7. Host conditioning and rejection monitoring in hepatocyte transplantation in humans [O] . Kyle A. Soltys, Kentaro Setoyama, Edgar N. Tafaleng, 2017

机译：人类肝细胞移植中的宿主调理和排斥监测

Host conditioning and rejection monitoring in hepatocyte transplantation in humans

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