Immunogenomic landscape of hepatocellular carcinoma with immune cell stroma and EBV-positive tumor-infiltrating lymphocytes

Kang Hyo Jeong; Oh Ji-Hye; Chun Sung-Min; Kim Deokhoon; Ryu Yeon-Mi; Hwang Hee Sang; Kim Sang-Yeob; An Jihyun; Cho Eun Jeong; Lee Hyeonjin; Shim Ju Hyun; Sung Chang Ohk; Yu Eunsil

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Immunogenomic landscape of hepatocellular carcinoma with immune cell stroma and EBV-positive tumor-infiltrating lymphocytes

机译：免疫细胞基质和EBV阳性肿瘤浸润淋巴细胞免疫导体肝癌的免疫因子景观

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Background & aims: The immunogenomic characteristics of hepatocellular carcinomas (HCCs) with immune cell stroma (HCC-IS), defined histologically, have not been clarified. We investigated the clinical and molecular features of HCC-IS and the prognostic impact of Epstein-Barr virus (EBV) infection.

机译：背景＆AIMS：没有澄清在组织学上定义的免疫细胞基质（HCCS）的肝细胞癌（HCCS）的免疫因子特征，并未澄清。我们研究了HCC-IS的临床和分子特征和Epstein-Barr病毒（EBV）感染的预后影响。

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来源
《Journal of Hepatology: The Journal of the European Association for the Study of the Liver》 |2019年第1期|共13页
作者
Kang Hyo Jeong; Oh Ji-Hye; Chun Sung-Min; Kim Deokhoon; Ryu Yeon-Mi; Hwang Hee Sang; Kim Sang-Yeob; An Jihyun; Cho Eun Jeong; Lee Hyeonjin; Shim Ju Hyun; Sung Chang Ohk; Yu Eunsil;
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作者单位

Univ Ulsan Asan Med Ctr Dept Pathol Coll Med 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

Univ Ulsan Asan Med Inst Convergence Sci &

Technol Dept Med Sci Coll Med Seoul South Korea;

Univ Ulsan Asan Med Ctr Dept Pathol Coll Med 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

Univ Ulsan Asan Med Ctr Dept Pathol Coll Med 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

Asan Med Ctr Asan Inst Life Sci Seoul South Korea;

Univ Ulsan Asan Med Ctr Dept Pathol Coll Med 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

Asan Med Ctr Asan Inst Life Sci Seoul South Korea;

Univ Ulsan Asan Med Ctr Dept Gastroenterol Coll Med 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

Univ Ulsan Asan Med Inst Convergence Sci &

Technol Dept Med Sci Coll Med Seoul South Korea;

Univ Ulsan Asan Med Inst Convergence Sci &

Technol Dept Med Sci Coll Med Seoul South Korea;

Univ Ulsan Asan Med Ctr Dept Gastroenterol Coll Med 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

Univ Ulsan Asan Med Ctr Dept Pathol Coll Med 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

Univ Ulsan Asan Med Ctr Dept Pathol Coll Med 88 Olymp Ro 43 Gil Seoul 05505 South Korea;

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
Hepatocellular carcinoma; Immune; Epstein-Barr virus; Sequencing;

机译：肝细胞癌;免疫;Epstein-Barr病毒;测序;

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专利

1. Immunogenomic landscape of hepatocellular carcinoma with immune cell stroma and EBV-positive tumor-infiltrating lymphocytes [J] . Kang Hyo Jeong, Oh Ji-Hye, Chun Sung-Min, Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2019,第1期

机译：免疫细胞基质和EBV阳性肿瘤浸润淋巴细胞免疫导体肝癌的免疫因子景观
2. A different representation of natural T cells and natural killer cells between tumor-infiltrating and periphery lymphocytes in human hepatocellular carcinoma [J] . Li Xia-Feng, Dai Dong, Song Xiu-Yu, Oncology letters . 2017,第5aPta1期

机译：人肝癌肿瘤渗透与周围淋巴细胞之间的天然T细胞和天然杀伤细胞的不同表示
3. Prognostic significances of tumor-infiltrating S-100 positive dendritic cells and lymphocytes in patients with hepatocellular carcinoma. [J] . Yin XY, Lu MD, Lai YR, Hepato-gastroenterology. . 2003,第53期

机译：肿瘤浸润的S-100阳性树突状细胞和淋巴细胞在肝细胞癌患者中的预后意义。
4. RNA-seq Analyses Generate Comprehensive Transcriptomic Landscape and Reveal Complex Transcript Patterns in Hepatocellular Carcinoma [C] . Qichao Huang, Dong Wu, Feng Shen, 2011 Asia-Pacific Conference of tumor biology and medicine . 2011

机译：RNA序列分析产生肝细胞癌的综合转录组景观和揭示复杂的转录模式。
5. The anti-cancer activities of Paeoniae Radix extracts on human hepatocellular carcinoma cell-line HepG2 and multidrug resistant human hepatocellular carcinoma cell-line R-HepG2 and their action mechanisms. [D] . Li, Lok Yee Mandy. 2004

机译：e药提取物对人肝癌细胞HepG2和多药耐药人肝癌细胞R-HepG2的抗癌活性及其作用机制。
6. Correction to: CTLA4 has a profound impact on the landscape of tumor-infiltrating lymphocytes with a high prognosis value in clear cell renal cell carcinoma (ccRCC) [O] . Shiyi Liu, Feiyan Wang, Wei Tan, 2021

机译：校正：CTLA4对肿瘤浸润淋巴细胞的景观产生深远的影响在透明细胞肾细胞癌（CCRCC）中具有高预后值
7. Expression Characteristics of Surface Markers of Memory T cells, CD45RO, CCR7 and CD62L, in Tumor-infiltrating Lymphocytes in Liver Cancer Tissues of Patients with Hepatocellular Carcinomas [O] . Bi-Wei Luo Xiao-Dong Yuan 2013

机译：肝细胞癌患者肝癌组织肿瘤浸润淋巴细胞中记忆T细胞，CD45RO，CCR7和CD62L表面标志物的表达特征

Immunogenomic landscape of hepatocellular carcinoma with immune cell stroma and EBV-positive tumor-infiltrating lymphocytes

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