Inferring the potentially complex genetic architectures of adaptation, sexual dimorphism and genotype by environment interactions by partitioning of mean phenotypes

Armstrong Andrew; Anderson Nathan W.; Blackmon Heath

摘要

Abstract >Genetic architecture fundamentally affects the way that traits evolve. However, the mapping of genotype to phenotype includes complex interactions with the environment or even the sex of an organism that can modulate the expressed phenotype. Line‐cross analysis is a powerful quantitative genetics method to infer genetic architecture by analysing the mean phenotype value of two diverged strains and a series of subsequent crosses and backcrosses. However, it has been difficult to account for complex interactions with the environment or sex within this framework. We have developed extensions to line‐cross analysis that allow for gene by environment and gene by sex interactions. Using extensive simulation studies and reanalysis of empirical data, we show that our approach can account for both unintended environmental variation when crosses cannot be reared in a common garden and can be used to test for the presence of gene by environment or gene by sex interactions. In analyses that fail to account for environmental variation between crosses, we find that line‐cross analysis has low power and high false‐positive rates. However, we illustrate that accounting for environmental variation allows for the inference of adaptive divergence, and that accounting for sex differences in phenotypes allows practitioners to infer the genetic architecture of sexual dimorphism. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“JEB13421-ABS-AB-ABS-0001”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >遗传架构从根本上影响了特征的方式影响了特征的方式发展。然而，基因型对表型的映射包括与环境或甚至可以调节表达表型的生物体的复杂相互作用。线交叉分析是一种强大的定量遗传学方法，可通过分析两种分歧菌株的平均表型值和一系列后续交叉和横频来推断出遗传架构。但是，难以在本框架内与环境或性别进行复杂的互动。我们已经开发了对线交叉分析的延伸，允许通过性互动进行环境和基因的基因。使用经验数据的广泛模拟研究和再分析，我们表明，当十字路口不能在共同的花园中饲养时，我们的方法可以考虑意外环境变异，并且可以用于通过性互动测试环境或基因的基因存在。在未能考虑交叉之间环境变异的分析中，我们发现线路交叉分析具有低功率和高误率。然而，我们说明了环境变异的核算允许推理适应性分歧，并且表型中的性别差异占性差允许从业者推断出性别二态的遗传建筑。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34394/'>《Journal of evolutionary biology》</a> <b style="margin: 0 2px;">|</b><span>2019年第4期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Armstrong Andrew&option=202" target="_blank" rel="nofollow">Armstrong Andrew;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Anderson Nathan W.&option=202" target="_blank" rel="nofollow">Anderson Nathan W.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Blackmon Heath&option=202" target="_blank" rel="nofollow">Blackmon Heath;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of MathematicsTexas A&</p> <p>M UniversityCollege Station Texas;</p> <p>Department of MathematicsTexas A&</p> <p>M UniversityCollege Station Texas;</p> <p>Department of BiologyTexas A&</p> <p>M UniversityCollege Station Texas;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a><a href="https://www.zhangqiaokeyan.com/clc/1283.html" title="生物演化与发展">生物演化与发展;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=environmental effect&option=203" rel="nofollow">environmental effect;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=epistasis&option=203" rel="nofollow">epistasis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=G?×?E&option=203" rel="nofollow">G?×?E;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=line‐cross analysis&option=203" rel="nofollow">line‐cross analysis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=sexual dimorphism&option=203" rel="nofollow">sexual dimorphism;</a> </p> <div class="translation"> 机译：环境效果;超越;G？×e;线交叉分析;性别二态性; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025533689.html">Inferring the potentially complex genetic architectures of adaptation, sexual dimorphism and genotype by environment interactions by partitioning of mean phenotypes</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Armstrong Andrew&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Armstrong Andrew,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Anderson Nathan W.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Anderson Nathan W.,</a> <a 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