Pathomorphological criteria of use efficiency of resorbable and permanent implants in aesthetic medicine and cosmetic dermatology

摘要

Summary Background The use of threads in aesthetic medicine is based on its ability to stimulate collagen production, which is claimed by the manufacturers, but this information has no basis at all, as no research has been carried out that would confirm the claimed information. Aims To determine effectiveness of collagenogenesis as a result of setting of resorbing and permanent implants on the basis of study pathomorphological changes in the skin. Methods The studies were performed on 30 mature white male rats which were divided into two groups depending on the type of implanted threads. Results Dependence between type of implantation thread (structure) and stimulation of collagenogenesis has been established. Conclusions While studying morphological changes in the peri‐implant zone, it was found that in all groups of experimental rats, collagen with different term of biodegradation and in different quantities on various chronological stages is formed. It was established that collagenogenesis is stimulated unevenly, depending on the type of implantation thread (chemical composition and structure). On the 90th day of the experiment, the resorbing thread did not completely degrade, which does not contradict the information provided by the manufacturer about the period of disintegration (365?days), and the expediency of using these cosmetic threads in aesthetic dermatology for the purpose of prolonged lifting skin correction. The specificity of the structure of implant threads, namely, the form of a spring (AS), as a provocative factor for long‐term alteration, causes long‐term inflammatory response in tissues (90th day of the experiment).