Effects of Pu-erh ripened tea on hyperuricemic mice studied by serum metabolomics

摘要

Highlights?Serum metabolomics based on GC–MS was employed in this study.?Twelve potential biomarkers associated with hyperuricemia were identified.?Pu-erh ripened tea caused anti-hyperuricemia in mice.?A mechanism of Pu-erh ripened tea effects may be modifying amino acid metabolism.AbstractTo evaluate effects of Pu-erh ripened tea in hyperuricemic mice, a mouse hyperuricemia model was developed by oral administration of potassium oxonate for 7 d. Serum metabolomics, based on gas chromatography–mass spectrometry, was used to generate metabolic profiles from normal control, hyperuricemic and allopurinol-treated hyperuricemic mice, as well as hyperuricemic mice given Pu-erh ripened tea at three doses. Pu-erh ripened tea significantly lowered serum uric acid levels. Twelve potential biomarkers associated with hyperuricemia were identified. Pu-erh ripened tea and allopurinol differed in their metabolic