Total cellular HIV-1 DNA decreases after switching to raltegravir-based regimens in patients with suppressed HIV-1 RNA

Rossetti Barbara; Meini Genny; Bianco Claudia; Lamonica Silvia; Mondi Annalisa; Belmonti Simone; Fanti Iuri; Ciccarelli Nicoletta; Di Giambenedetto Simona; Zazzi Maurizio; De Luca Andrea

首页> 外文期刊>Journal of clinical virology: The official publication of the Pan American Society for Clinical Virology >Total cellular HIV-1 DNA decreases after switching to raltegravir-based regimens in patients with suppressed HIV-1 RNA

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Total cellular HIV-1 DNA decreases after switching to raltegravir-based regimens in patients with suppressed HIV-1 RNA

机译：在抑制HIV-1 RNA患者的患者切换到基于RALTEGRAVIR的方案后，总细胞HIV-1 DNA降低

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Background: The integrase inhibitor raltegravir has been used to intensify antiretroviral therapy in patients with undetectable plasma HIV-1RNA, resulting in variable perturbation of HIV-1 nucleic acids levels in peripheral blood.

机译：背景：整合酶抑制剂Raltegravir已被用于加强抗逆转录病毒治疗患者的血浆HIV-1RNA患者，导致外周血中HIV-1核酸水平的可变性扰动。

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来源
《Journal of clinical virology: The official publication of the Pan American Society for Clinical Virology》 |2017年第2017期|共7页
作者
Rossetti Barbara; Meini Genny; Bianco Claudia; Lamonica Silvia; Mondi Annalisa; Belmonti Simone; Fanti Iuri; Ciccarelli Nicoletta; Di Giambenedetto Simona; Zazzi Maurizio; De Luca Andrea;
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作者单位

Azienda Osped Univ Senese Infect Dis Unit Siena Italy;

Univ Siena Med Biotechnol Dept Siena Italy;

Azienda Osped Univ Senese Infect Dis Unit Siena Italy;

Univ Cattolica Sacro Cuore Clin Infect Dis Rome Italy;

Univ Cattolica Sacro Cuore Clin Infect Dis Rome Italy;

Univ Cattolica Sacro Cuore Clin Infect Dis Rome Italy;

Univ Cattolica Sacro Cuore Clin Infect Dis Rome Italy;

Univ Cattolica Sacro Cuore Clin Infect Dis Rome Italy;

Univ Cattolica Sacro Cuore Clin Infect Dis Rome Italy;

Univ Siena Med Biotechnol Dept Siena Italy;

Azienda Osped Univ Senese Infect Dis Unit Siena Italy;

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原文格式 PDF
正文语种 eng
中图分类医学微生物学（病原细菌学、病原微生物学）;
关键词
HIV-1 DNA; HIV-1 reservoir; Ultrasensitive HIV-1 RNA; Raltegravir; Integrase inhibitors;

机译：HIV-1 DNA;HIV-1储层;超敏HIV-1 RNA;Raltegravir;整合酶抑制剂;

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专利

1. Total cellular HIV-1 DNA decreases after switching to raltegravir-based regimens in patients with suppressed HIV-1 RNA [J] . Rossetti Barbara, Meini Genny, Bianco Claudia, Journal of clinical virology: The official publication of the Pan American Society for Clinical Virology . 2017,第期

机译：在抑制HIV-1 RNA患者的患者切换到基于RALTEGRAVIR的方案后，总细胞HIV-1 DNA降低
2. Time course of total HIV-1 DNA and 2-long-terminal repeat circles in patients with controlled plasma viremia switching to a raltegravir-containing regimen. [J] . Delaugerre C, Charreau I, Braun J, AIDS . 2010,第15期

机译：在控制血浆病毒血症的患者中，总HIV-1 DNA和2个长末端重复循环的时程转换为含raltegravir的治疗方案。
3. HIV-1 residual viremia and proviral DNA in patients with suppressed plasma viral load (<400 HIV-RNA cp/ml) during different antiretroviral regimens. [J] . Nicastri E, Palmisano L, Sarmati L, Current HIV research . 2008,第3期

机译：在不同抗逆转录病毒治疗方案中血浆病毒载量被抑制（<400 HIV-RNA cp / ml）的患者中的HIV-1残留病毒血症和前病毒DNA。
4. Down-regulation of HIV-1 long terminal repeat controlled viral transcription by DNA-binding,arginine-rich fusion proteins derived from HIV-1 TAT for the direct delivery into the nucleus [C] . Stefan R.K.Hoffmann the International Peptide Symposium . 2001

机译：通过DNA结合的HIV-1长末端重复受控病毒转录的下调，从HIV-1 TAT衍生的精氨酸富融合蛋白，用于直接输送到细胞核中
5. The use of RNA technologies to decrease HIV-1 replication and investigate the role of RNA interference in the innate immune response to HIV-1 infection. [D] . Soye, Kaitlin Jane. 2008

机译：使用RNA技术减少HIV-1复制并研究RNA干扰在对HIV-1感染的固有免疫应答中的作用。
6. Switch to raltegravir-based regimens and HIV DNA decrease in patients with suppressed HIV RNA [O] . Claudia Bianco, Genny Meini, Barbara Rossetti, 2014

机译：改用基于raltegravir的方案HIV RNA受抑制的患者的HIV DNA减少
7. Switch to raltegravir-based regimens and HIV DNA decrease in patients with suppressed HIV RNA [O] . Claudia Bianco, Genny Meini, Barbara Rossetti, 2014

机译：切换到基于raltegravir的方案和HIV RNa被抑制的患者的HIV DNa减少
8. High Dose Atorvastatin Decreases Cellular Markers of Immune Activation Without Affecting HIV-1 RNA Levels: Results of a Double-Blind Randomized Placebo Controlled Clinical Trial [R] . Ganesan, A., Crum-Cianflone, N., Higgins, J., 2011

机译：高剂量阿托伐他汀减少免疫激活的细胞标记而不影响HIV-1 RNa水平：双盲随机安慰剂对照临床试验的结果

Total cellular HIV-1 DNA decreases after switching to raltegravir-based regimens in patients with suppressed HIV-1 RNA

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