Increase in acid sphingomyelinase Level in human retinal endothelial cells and CD34(+) circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes

Kady Nermin; Yan Yuanqing; Salazar Tatiana; Wang Qi; Chakravarthy Harshini; Huang Chao; Beli Eleni; Navitskaya Svetlana; Grant Maria; Busik Julia

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Increase in acid sphingomyelinase Level in human retinal endothelial cells and CD34(+) circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes

机译：人类视网膜内皮细胞中的酸鞘磷脂酶水平和从糖尿病个体中分离的CD34（+）循环血管生成细胞与糖尿病中的功能障碍视网膜血管系统和血管修复过程有关

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BACKGROUND: Diabetic retinopathy is a microvascular disease that results from retinal vascular degeneration and defective repair due to diabetes-induced endothelial progenitor dysfunction.

机译：背景：糖尿病视网膜病变是一种微血管疾病，由视网膜血管变性和由于糖尿病诱导的内皮祖细胞功能障碍而导致的缺陷修复。

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《Journal of clinical lipidology》 |2017年第3期|共10页
作者
Kady Nermin; Yan Yuanqing; Salazar Tatiana; Wang Qi; Chakravarthy Harshini; Huang Chao; Beli Eleni; Navitskaya Svetlana; Grant Maria; Busik Julia;
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作者单位

Michigan State Univ Dept Physiol E Lansing MI 48824 USA;

Univ Texas MD Anderson Canc Ctr Dept Biostat Houston TX 77030 USA;

Univ Florida Dept Pharmacol &

Therapeut Genet &

Genom Grad Program Gainesville FL USA;

Michigan State Univ Dept Physiol E Lansing MI 48824 USA;

Michigan State Univ Dept Physiol E Lansing MI 48824 USA;

Michigan State Univ Dept Physiol E Lansing MI 48824 USA;

Indiana Univ Sch Med Dept Ophthalmol Indianapolis IN 46202 USA;

Michigan State Univ Dept Physiol E Lansing MI 48824 USA;

Indiana Univ Sch Med Dept Ophthalmol Indianapolis IN 46202 USA;

Michigan State Univ Dept Physiol E Lansing MI 48824 USA;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
Diabetic retinopathy; Acid sphingomyelinase; Circulating angiogenic cells; Revascularization;

机译：糖尿病视网膜疗法;酸鞘磷脂酶;循环血管生成细胞;血运重建;

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1. Increase in acid sphingomyelinase Level in human retinal endothelial cells and CD34(+) circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes [J] . Kady Nermin, Yan Yuanqing, Salazar Tatiana, Journal of clinical lipidology . 2017,第3期

机译：人类视网膜内皮细胞中的酸鞘磷脂酶水平和从糖尿病个体中分离的CD34（+）循环血管生成细胞与糖尿病中的功能障碍视网膜血管系统和血管修复过程有关
2. Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature [J] . Jiang Youde, Liu Li, Steinle Jena J. Investigative ophthalmology & visual science . 2017,第1期

机译：化合物49B调节人视网膜内皮细胞和小鼠视网膜脉管系统中的ZO-1和闭塞素水平
3. Application of magnetically isolated rat retinal vascular endothelial cells for the determination of transporter gene expression levels at the inner blood-retinal barrier. [J] . Tomi M, Hosoya K Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2004,第5期

机译：磁性分离的大鼠视网膜血管内皮细胞在确定内血-视网膜屏障中转运蛋白基因表达水平中的应用。
4. Differentiation of side population cells isolated from human amniotic mesenchymal cells into vascular endothelial cells [C] . Naoko Maruyama, Kenichi Kokubo, Toshihiro Shinbo, World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：从人羊膜间充质细胞分离的侧群细胞分化为血管内皮细胞
5. Norrin, Frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. [D] . Ye, Xin. 2010

机译：内皮细胞中的Norrin，Frizzled-4和Lrp5信号控制着视网膜血管化的遗传程序。
6. Increase in acid sphingomyelinase level in human retinal endothelial cells and CD34+ circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes [O] . Nermin Kady, Yuanqing Yan, Tatiana Salazar, -1

机译：从糖尿病个体中分离出的人视网膜内皮细胞和CD34 +循环血管生成细胞中的酸性鞘磷脂酶水平升高与糖尿病性视网膜血管功能障碍和血管修复过程有关
7. Increase in acid sphingomyelinase level in human retinal endothelial cells and CD34+ circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes [O] . Department of Physiology, Michigan State University, East Lansing, MI, USA ( host institution ), Kady, Nermin ( author ), Yan, Yuanqing ( author ), 2017

机译：从糖尿病患者中分离出的人视网膜内皮细胞和CD34 +循环血管生成细胞中酸性鞘磷脂酶水平的升高与糖尿病性视网膜血管功能障碍和血管修复过程有关

Increase in acid sphingomyelinase Level in human retinal endothelial cells and CD34(+) circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes

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