Microwave-assisted synthesis of isoindolinones via Pd-mediated tandem coupling reactions

摘要

Palladium (Pd) coupling reactions have become an indispensable tool in modern synthetic organic chemistry. A simple procedure to obtain isoindolinones 7 bearing a quaternary C-atom, featuring a Pd-mediated tandem process, is presented. Readily available iodoamidoacrylate 3 and boronic acids 6 are used as the starting materials.