Assessing the speed of kill of hookworms, Ancylostoma caninum, by Advantage Multi (R) for Dogs using endoscopic methods

摘要

Endoscopic capsules and endoscopy were used to assess the speed of kill and the clearance of hookworms in dogs experimentally infected with Ancylostoma caninum. A total of four adult dogs were inoculated in two separate cohorts comprised of two 4-year-old females and two 7-year-old males. Dogs were treated topically with Advantage Multi (R) for Dogs 13 days (Cohort 1) or 16 days (Cohort 2) after infection. Endoscopic imaging of the small intestine was carried out both pre- and post-treatment. Examination of the first cohort revealed that the worms had been cleared and the hookworm-induced lacerations were markedly diminished within 48 h of treatment. In the second cohort, endoscopic capsules were given the day of, the day after, and two days after treatment; within 24 h of product administration, the worms had been removed with a concurrent reduction in observed lesions. Topical application of Advantage Multi (R) for Dogs rapidly removed worms from the small intestine of the dogs in this study as early as 24 h post-treatment, with a marked reduction in the number of mucosal lesions seen