Tolcapone Suppresses Ethanol Intake in Alcohol-Preferring Rats Performing a Novel Cued Access Protocol

摘要

Background: Dopamine (DA) has been shown to play a central role in regulating motivated behavior and encoding reward. Chronic drug abuse elicits a state of hypodopaminergia in the mesocorticolimbic (MCL) system in both humans and preclinical rodent models of addiction, including those modeling alcohol use disorders (AUD).