Solithromycin versus ceftriaxone plus azithromycin for the treatment of uncomplicated genital gonorrhoea (SOLITAIRE-U): a randomised phase 3 non-inferiority trial

Chen Marcus Y.; McNulty Anna; Avery Ann; Whiley David; Tabrizi Sepehr N.; Hardy Dwight; Das Anita F.; Nenninger Ashley; Fairley Christopher K.; Hocking Jane S.; Bradshaw Catriona S.; Donovan Basil; Howden Benjamin P.; Oldach David

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Solithromycin versus ceftriaxone plus azithromycin for the treatment of uncomplicated genital gonorrhoea (SOLITAIRE-U): a randomised phase 3 non-inferiority trial

机译：茄子霉素与头孢曲松加上阿奇霉素治疗外包生殖器淋病（Solitaire-U）：随机相3非劣级试验

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Background Antibiotic-resistant gonorrhoea represents a global public health threat, and new therapies are needed. We aimed to compare the efficacy and safety of solithromycin, a fourth generation macrolide, with ceftriaxone plus azithromycin for the treatment of gonorrhoea.

机译：背景技术抗生素毒性淋病代表全球公共卫生威胁，需要新的疗法。我们的旨在比较索尔霉素，第四代大胶质苷的疗效和安全性，Ceftriaxone加上阿奇霉素用于治疗淋病。

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《The Lancet infectious diseases》 |2019年第8期|共10页
作者
Chen Marcus Y.; McNulty Anna; Avery Ann; Whiley David; Tabrizi Sepehr N.; Hardy Dwight; Das Anita F.; Nenninger Ashley; Fairley Christopher K.; Hocking Jane S.; Bradshaw Catriona S.; Donovan Basil; Howden Benjamin P.; Oldach David;
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作者单位

Alfred Hlth Melbourne Sexual Hlth Ctr Melbourne Vic 3053 Australia;

Sydney Hosp Sydney Sexual Hlth Ctr Sydney NSW Australia;

MetroHlth Med Ctr Cleveland OH USA;

Univ Queensland Queensland Childrens Med Res Inst Brisbane Qld Australia;

Univ Melbourne Dept Obstet &

Gynaecol Melbourne Vic Australia;

Univ Rochester Med Ctr Rochester NY 14642 USA;

AD Stat Guerneville CA USA;

Cempra Pharmaceut Chapel Hill NC USA;

Alfred Hlth Melbourne Sexual Hlth Ctr Melbourne Vic 3053 Australia;

Univ Melbourne Melbourne Sch Populat &

Global Hlth Melbourne Vic Australia;

Alfred Hlth Melbourne Sexual Hlth Ctr Melbourne Vic 3053 Australia;

Sydney Hosp Sydney Sexual Hlth Ctr Sydney NSW Australia;

Univ Melbourne Microbiol Diagnost Unit Publ Hlth Lab Doherty Inst Infect &

Immun Melbourne Vic;

Cempra Pharmaceut Chapel Hill NC USA;

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正文语种 eng
中图分类传染病;
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1. Solithromycin versus ceftriaxone plus azithromycin for the treatment of uncomplicated genital gonorrhoea (SOLITAIRE-U): a randomised phase 3 non-inferiority trial [J] . Chen Marcus Y., McNulty Anna, Avery Ann, The Lancet infectious diseases . 2019,第8期

机译：茄子霉素与头孢曲松加上阿奇霉素治疗外包生殖器淋病（Solitaire-U）：随机相3非劣级试验
2. Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial (vol 393, pg 2511, 2019) [J] . Ross J. D. C., Brittain C., Cole M. The Lancet . 2019,第10205期

机译：庆大霉素与头孢曲松的治疗淋病（G-TOG）：随机非劣级试验（Vol 393，PG 2511,2019）进行治疗
3. Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial [J] . Ross Jonathan D. C., Brittain Clare, Cole Michelle, The Lancet . 2019,第10190期

机译：庆大霉素与头孢曲松进行淋病（G-TOG）的治疗（G-TOG）：随机的非劣升性试验
4. Non-inferiority Trial Comparing a First Generation Cephalosporin with a Third Generation Cephalosporin in the Treatment of Non-severe Clinical Mastitis in Dairy Cows [C] . Ynte h. Schukken, Mike J. Zurakowski, Brad J. Rauch, Annual Meeting of the National^Mastitis^Council . 2013

机译：非劣种试验比较第一代头孢菌素与第三代头孢菌素治疗奶牛非严重临床乳腺炎的治疗
5. Indirect pulp treatment versus formocresol pulpotomy in human primary molars: A randomized controlled trial. [D] . Roberts, John David. 2009

机译：在人原发性磨牙中间接牙髓治疗与甲酚甲切开术：一项随机对照试验。
6. AQ-13 an investigational antimalarial versus artemether plus lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria: a randomised phase 2 non-inferiority clinical trial [O] . Ousmane A Koita, Lansana Sangaré, Haiyan D Miller, -1

机译：AQ-13一种抗疟疾的研究性药物与蒿甲醚+ lumefantrine相比用于治疗单纯性恶性疟原虫疟疾：一项随机2期非劣效性临床试验
7. Gentamicin versus ceftriaxone for the treatment of gonorrhoea (G-TOG trial): study protocol for a randomised trial [O] . Clare Brittain, Margaret Childs, Lelia Duley, 2016

机译：庆大霉素与头孢曲松钠治疗淋病（G-TOG试验）：一项随机试验的研究方案

Solithromycin versus ceftriaxone plus azithromycin for the treatment of uncomplicated genital gonorrhoea (SOLITAIRE-U): a randomised phase 3 non-inferiority trial

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