A Pilot Trial of Cisplatin/Etoposide/Radiotherapy Followed by Consolidation Docetaxel and the Combination of Bevacizumab (NSC-704865) in Patients With Inoperable Locally Advanced Stage III Non-Small-Cell Lung Cancer: SWOG S0533

摘要

The incorporation of bevacizumab with concurrent chemoradiotherapy (CRT) in the treatment of locally advanced nonesmall-cell lung cancer (NSCLC) could improve efficacy in this disease stage. In this trial we accrued patients in 2 strata (high and low risk for hemoptysis) and in 3 separate cohorts depending on the timing of the bevacizumab. Bevacizumab could not be safely integrated or effectively combined with CRT in inoperable NSCLC patients. Future trials combining bevacizumab and CRT are not warranted.