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首页> 外文期刊>The anatomical record: advances in integrative anatomy and evolutionary biology >Comparative Evaluation of Chitosan Nerve Guides with Regular or Increased Bendability for Acute and Delayed Peripheral Nerve Repair: A Comprehensive Comparison with Autologous Nerve Grafts and Muscle‐in‐Vein Grafts
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Comparative Evaluation of Chitosan Nerve Guides with Regular or Increased Bendability for Acute and Delayed Peripheral Nerve Repair: A Comprehensive Comparison with Autologous Nerve Grafts and Muscle‐in‐Vein Grafts

机译:对胰酸的神经指导常规或增加急性周围神经修复性的壳聚糖神经指导的比较评价:与自体神经移植物和肌肉内移植物的全面比较

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ABSTRACT Reconstruction of joint‐crossing digital nerves requires the application of nerve guides with a much higher flexibility than used for peripheral nerve repair along larger bones. Nevertheless, collapse‐resistance should be preserved to avoid secondary damage to the regrowing nerve tissue. In recent years, we presented chitosan nerve guides (CNGs) to be highly supportive for the regeneration of critical gap length peripheral nerve defects in the rat. Now, we evidently increased the bendability of regular CNGs (regCNGs) by developing a wavy wall structure, that is, corrugated CNGs (corrCNGs). In a comprehensive in vivo study, we compared both types of CNGs with clinical gold standard autologous nerve grafts (ANGs) and muscle‐in‐vein grafts (MVGs) that have recently been highlighted in the literature as a suitable alternative to ANGs. We reconstructed rat sciatic nerves over a critical gap length of 15?mm either immediately upon transection or after a delay period of 45?days. Electrodiagnostic measurements were applied to monitor functional motor recovery at 60, 90, 120, and 150 (only delayed repair)?days postreconstruction. Upon explanation, tube properties were analyzed. Furthermore, distal nerve ends were evaluated using histomorphometry, while connective tissue specimens were subjected to immunohistological stainings. After 120?days (acute repair) or 150?days (delayed repair), respectively, compression–stability of regCNGs was slightly increased while it remained stable in corrCNGs. In both substudies, regCNGs and corrCNGs supported functional recovery of distal plantar muscles in a similar way and to a greater extent when compared with MVGs, while ANGs demonstrated the best support of regeneration. Anat Rec, 301:1697–1713, 2018. ? 2018 Wiley Periodicals, Inc.
机译:摘要联合交叉数字神经的重建需要沿着较大骨骼的周围神经修复的柔韧性更高的灵活性。然而,应保存塌陷抗性以避免对遗弃神经组织的二次损害。近年来,我们介绍了壳聚糖神经指南(CNG),高度支持大鼠临界间隙长度周围神经缺陷的再生。现在,我们通过开发波浪墙体结构而显着提高了常规CNG(Regcngs)的趋势,即波纹CNG(Corrcngs)。在全面的体内研究中,我们将两种类型的CNG与最近在文献中突出的临床金标准自体神经移植物(Angs)和静脉内移植物(MVG)的肌肉 - 静脉移植物(MVG)进行了较近的angs的合适替代品。在横断调或45℃的延迟期后,我们在临界间隙长度为15Ωmm的临界间隙长度或在45?天后重建大鼠坐骨神经。应用电渗量测量以监测60,90,120和150(仅延迟修复)的功能性电动机恢复?天Postreconstruction。解释后,分析了管性质。此外,使用组织形态学评估远端神经末端,而结缔组织标本经受免疫组织染色。经过120℃(急性修复)或150?天(延迟修复),Regcngs的压缩稳定性略微增加,而在Corrcngs中保持稳定。在偶然的情况下,Regcngs和Corrcngs在与MVG的比较时,在类似的方式和更大程度上支持肌动植物肌的功能恢复,而Angs表现出最佳再生的支持。 ANAT REC,301:1697-1713,2018 2018年Wiley期刊,Inc。

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